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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
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Published on: March 18, 2014

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A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.

Daniela Loessner1, Anja Rockstroh2, Ali Shokoohmand2

  • 1Barts Cancer Institute, Queen Mary University of London, London, United Kingdom; Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059, Australia.

Biomaterials
|November 6, 2018
PubMed
Summary

Researchers developed a 3D ovarian cancer model to study peritoneal invasion. This model identified key factors like IGFBP7, PTGS2, VEGFC, and FGF2 that promote metastasis, potentially leading to new therapies.

Keywords:
HydrogelMesothelial cellsOvarian cancerScaffoldTumor microenvironment

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