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Nortriptyline-induced oral ulceration: A case report.
William Olsufka1, Danielle Cabral2, Megan McArdle2
1(Corresponding author) Assistant Professor, Pharmacy Practice Department, Touro College of Pharmacy, New York, New York; Psychiatry Clinical Pharmacist, Mount Sinai Beth Israel Hospital, New York, New York, williamolsufka@gmail.com.
The Mental Health Clinician
|November 7, 2018
Summary
This case report details the first instance of oral ulcers caused by the antidepressant nortriptyline. Symptoms resolved after discontinuing the drug, highlighting a potential adverse effect.
Area of Science:
- Pharmacology
- Oral Medicine
- Dermatology
Background:
- Drug-induced oral ulcers are painful lesions on the oral mucosa.
- Symptoms can include burning mouth, metallic taste, dysgeusia, or ageusia.
- Tricyclic antidepressants are commonly used for various conditions.
Observation:
- A 49-year-old female developed painful, oral, bubble-like ulcers.
- These ulcers appeared within two weeks of starting nortriptyline treatment for refractory neuropathy.
- Symptoms completely resolved about one month after discontinuing nortriptyline.
Findings:
- This is the first documented case of drug-induced oral ulcers associated with nortriptyline.
- The exact mechanism by which nortriptyline may induce oral ulcers is currently unknown.
Implications:
- Clinicians should be aware of nortriptyline as a potential cause of drug-induced oral ulcers.
- This finding may prompt further investigation into the adverse effects of nortriptyline.
- Recognition of this potential side effect can aid in timely diagnosis and management of oral ulcerations.
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