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Related Experiment Videos

Bioptically Proven "Anticoagulation-Related Nephropathy" Induced by Dual Antiplatelet Therapy.

Karolína Krátká1, Martin Havrda1, Eva Honsová2

  • 11st Department of Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Case Reports in Nephrology and Dialysis
|November 7, 2018
PubMed
Summary

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Anticoagulation-related nephropathy (ARN) can occur with novel oral anticoagulants. This case study presents ARN in a patient receiving only dual antiplatelet therapy, challenging current understanding.

Area of Science:

  • Nephrology
  • Hematology
  • Pathology

Background:

  • Anticoagulation-related nephropathy (ARN) is a kidney complication associated with excessive anticoagulation, typically warfarin (INR > 3.0).
  • Diagnosis involves renal biopsy showing acute tubular necrosis and red blood cell casts.
  • ARN has also been reported with novel oral anticoagulants.

Observation:

  • A case of an 82-year-old male patient is presented.
  • The patient developed biopsy-proven ARN.
  • He had received dual antiplatelet therapy without prior anticoagulation and had normal coagulation tests.

Findings:

  • This case suggests ARN can occur with dual antiplatelet therapy alone.
  • It challenges the established link between ARN and anticoagulation.
Keywords:
Acute kidney injuryAnticoagulation-related nephropathyDual antiplatelet therapyHematuria

Related Experiment Videos

  • Renal biopsy confirmed acute tubular necrosis and red blood cell casts.

    • Implications:

    • ARN may be underdiagnosed and potentially linked to antiplatelet agents.
    • Further research is needed to understand ARN mechanisms beyond anticoagulation.
    • This finding broadens the differential diagnosis for acute kidney injury in patients on antiplatelet therapy.