Related Experiment Video

Updated: Feb 3, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K

Prevention of pertussis: from clinical trials to Real World Evidence

S Esposito1

  • 1Pediatric Clinic, Department of Medical and Surgical Sciences, Università degli Studi di Perugia, Italy.

Journal of Preventive Medicine and Hygiene
|November 7, 2018
PubMed

Insights

Strengthening pertussis (whooping cough) vaccination coverage in all age groups, including maternal vaccination during pregnancy, is crucial for preventing this widespread infectious disease. This approach protects newborns before they can be vaccinated.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Vaccinology

Background:

  • Pertussis, caused by Bordetella pertussis, historically posed significant health and economic burdens, particularly for infants.
  • While whole-cell and acellular pertussis vaccines have reduced disease incidence, pertussis remains a prevalent vaccine-preventable illness.
  • Recent years have seen an increase in pertussis cases, highlighting ongoing challenges in disease control.

Purpose of the Study:

  • To review the current understanding of pertussis epidemiology and vaccine effectiveness.
  • To emphasize the necessity of updated vaccination strategies for comprehensive pertussis prevention.
  • To highlight the critical role of maternal immunization in protecting newborns.

Main Methods:

  • Review of existing literature on pertussis epidemiology, vaccine efficacy, and public health recommendations.
  • Analysis of trends in pertussis incidence and vaccine coverage.
  • Evaluation of the impact of different vaccination schedules and strategies.

Main Results:

  • Acellular pertussis vaccines demonstrate good immunogenicity and real-world effectiveness.
  • Despite vaccination efforts, pertussis incidence is increasing in some populations.
  • Maternal vaccination during the third trimester is highly effective in protecting infants.

Conclusions:

  • Enhanced and consistent vaccination coverage across all age groups is essential for controlling pertussis.
  • Booster vaccinations every 10 years are recommended for sustained immunity in adults.
  • Maternal vaccination is a key strategy to provide immediate protection to newborns against pertussis.

Keywords:
PertussisPertussis preventionPertussis vaccines

More Related Videos

Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides05:16

Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides

Published on: May 7, 2020

7.3K
Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay14:45

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

15.5K

Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.5K
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.2K
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.5K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
420
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.1K