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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Chronic Periaortitis: an Update.

Alessandra Palmisano1, Federica Maritati1, Augusto Vaglio2,3

  • 1Nephrology Unit, Parma University Hospital, Parma, Italy.

Current Rheumatology Reports
|November 7, 2018
PubMed
Summary
This summary is machine-generated.

Chronic periaortitis (CP) is a rare immune-mediated disease affecting the aorta. This review covers its nosology, pathophysiology, clinical features, and treatments, including immunosuppressive agents.

Keywords:
AortaChronic periaortitisFibro-inflammatory disorderIgG4IgG4-related diseaseRetroperitoneal fibrosisVasculitis

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Area of Science:

  • Vascular inflammation
  • Immunopathology
  • Rheumatology

Background:

  • Chronic periaortitis (CP) is characterized by periaortic fibro-inflammatory tissue.
  • It can be isolated or associated with IgG4-related disease spectrum manifestations.
  • Involvement of the thoracic aorta suggests an inflammatory disorder of large arteries.

Purpose of the Study:

  • To review traditional concepts and recent developments in chronic periaortitis (CP).
  • To cover the nosology, pathophysiology, clinical phenotypes, and treatment of CP.

Main Methods:

  • Literature review of traditional concepts and recent developments in CP.
  • Synthesis of information on disease spectrum, pathogenesis, and therapeutic strategies.

Main Results:

  • CP pathogenesis is multifactorial, involving immunogenetic variants and environmental exposures (smoking, asbestos).
  • CP affects the abdominal aorta, iliac arteries, and sometimes the thoracic aorta.
  • Treatment involves glucocorticoids, conventional, and biological immunosuppressive agents.

Conclusions:

  • Chronic periaortitis is a rare, immune-mediated disease with complex pathogenesis.
  • Understanding its association with IgG4-related disease is crucial for diagnosis and management.
  • Multifaceted treatment approaches are necessary for effective management of CP.