Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Control of Power Flow01:30

Control of Power Flow

695
There are several methods to control power flow in power systems:
695
Underflow Gates01:30

Underflow Gates

412
Underflow gates are vital for controlling water flow in irrigation canals. The three main types of underflow gates — vertical, radial, and drum gates — serve different purposes while ensuring effective flow management. Vertical gates move up and down, generating a free-flowing water jet; radial gates pivot to regulate the flow; and drum gates rotate for precise adjustments. The flow through these gates is influenced by downstream conditions, resulting in free or drowned outflow.Free and...
412
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

20.1K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.1K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.0K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.0K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

75.7K
Dipole Moment of a Molecule
75.7K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.2K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of KIT signaling promotes early tumorigenesis through the AP-1 pathway in APC/TP53 double-knockout human colon organoids.

Cell death & disease·2026
Same author

Sodium-Glucose Cotransporter-2 Inhibitors Are Associated with Improved Survival in Patients with Cirrhosis.

Journal of gastrointestinal and liver diseases : JGLD·2026
Same author

DeepRespNet: a hybrid attention-recurrent framework for non-contact respiratory rate estimation.

Frontiers in physiology·2026
Same author

Effects of ramped GVS parameter combinations on vestibular perception and their application in a Virtual Reality flight simulator.

Ergonomics·2026
Same author

High-strength and high-modulus silicon monoxide for high-energy-density and fast-charging lithium-ion batteries.

Nature communications·2026
Same author

Enhanced multicancer screening assay through whole-genome methylation sequencing-based multimodal cell-free DNA analysis.

Experimental & molecular medicine·2026

Related Experiment Video

Updated: Feb 3, 2026

Electric-field Control of Electronic States in WS2 Nanodevices by Electrolyte Gating
10:36

Electric-field Control of Electronic States in WS2 Nanodevices by Electrolyte Gating

Published on: April 12, 2018

12.0K

Electrically gated nanoporous membranes for smart molecular flow control.

Sungho Kim1, Ece Isenbike Ozalp, Mohamed Darwish

  • 1Department of Electrical & Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Nanoscale
|November 7, 2018
PubMed
Summary

We developed a smart drug delivery system using a conductive nanoporous membrane for electrically controlled drug release. This novel platform precisely manages therapeutic molecule transport via field-effect gating, showing promise for targeted glaucoma treatment.

More Related Videos

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

12.1K

Related Experiment Videos

Last Updated: Feb 3, 2026

Electric-field Control of Electronic States in WS2 Nanodevices by Electrolyte Gating
10:36

Electric-field Control of Electronic States in WS2 Nanodevices by Electrolyte Gating

Published on: April 12, 2018

12.0K
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

12.1K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Smart drug delivery systems require precise control over therapeutic molecule release.
  • Field-effect gating offers a potential mechanism for low-power, electrically controlled transport.
  • Nanoporous membranes provide a scaffold for fabricating miniaturized drug delivery devices.

Purpose of the Study:

  • To develop and characterize a novel conductive nanoporous membrane platform for electrically controlled drug delivery.
  • To investigate the use of field-effect gating for precise control of charged drug molecule transport.
  • To evaluate the platform's efficacy in delivering glaucoma treatment molecules.

Main Methods:

  • Fabrication of a functionalized anodic aluminum oxide (AAO) membrane with a Cr-Au-Cr stack.
  • Functionalization involved creating an insulating layer for gate electrode control.
  • Testing with oppositely charged drug molecules (ethacrynic acid and timolol maleate) at pH 7.4.

Main Results:

  • A +2 V gate voltage increased negatively charged ethacrynic acid transport by 337% and decreased positively charged timolol maleate transport by 66%.
  • A -2 V gate voltage decreased ethacrynic acid transport by 48% and increased timolol maleate transport by 116%.
  • Surface treatment affected the on-off ratio (OOR), altering drug transport control, with results verified by simulations.

Conclusions:

  • The developed conductive nanoporous membrane platform enables low-power, electrically controlled drug delivery via field-effect gating.
  • The system demonstrates precise control over the transport of oppositely charged drug molecules.
  • This technology holds potential for advanced smart drug delivery systems, particularly for conditions like glaucoma.