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Catalytic Asymmetric Hydrophosphination of ortho-Quinone Methides
Xiu Gu1, Hao Yuan1, Jun Jiang1
1School of Chemistry and Chemical Engineering , Guangxi University , Nanning 530004 , P. R. China.
Abstract:
An efficient catalytic asymmetric hydrophosphination of ortho-quinone methides with H-phosphine oxides is established. A chiral bifunctional squaramide is superior to catalyze this enantioselective carbon-phosphorus bond formation, delivering optically active α-arylmethyl phosphine oxides in high yields with high enantioselectivities (up to 94% yield, 99:1 er). Additionally, employing in situ-generated o-QMs for this hydrophosphination step economically provides the corresponding phosphine oxides with comparable yield and enantioselectivity.
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