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Updated: Sep 15, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Cobalt(III)-catalyzed C-H functionalization of 2-arylthiazoles with maleimides or allyl acetate
Pengfei Zhou1, Guibin Wan1, Zhihan Yuan1
1School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, P. R. China. jiangjun@gxu.edu.cn.
Abstract:
We report a cobalt-catalyzed C-H functionalization strategy for the modular alkylation and allylation of 2-arylthiazoles using maleimides or allyl acetates as coupling partners. This protocol enables efficient, ortho-selective C-H bond transformations in a single step, providing a broad range of functionalized thiazole derivatives. The developed methodology offers a novel and versatile platform for the direct C-H alkylation and allylation of 2-arylthiazole scaffolds, characterized by operational simplicity, a wide substrate scope, and high tolerance toward diverse functional groups.
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