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CATH: expanding the horizons of structure-based functional annotations for genome sequences
Ian Sillitoe1, Natalie Dawson1, Tony E Lewis1
1Structural and Molecular Biology, University College London WC1E 6BT, UK.
Nucleic Acids Research
|November 7, 2018
Summary
The CATH protein database (Common Architecture Tool Heuristics) now offers enhanced data coverage for protein structures. Version 4.2 significantly increases classified domains and predicted sequences, improving structural and functional analysis.
Area of Science:
- Structural bioinformatics
- Protein domain classification
Background:
- The CATH database classifies protein domain structures and superfamilies.
- It offers two release levels: CATH-B (daily updates) and CATH+ (derived data).
Purpose of the Study:
- To report on the latest data and developments in the CATH protein structure classification database.
- To highlight the significant updates in the CATH+ version 4.2 release.
Main Methods:
- Updating and expanding the CATH protein structure classification database.
- Incorporating predicted sequence domains, functional annotations, and Functional Families (FunFams).
- Enhancing web features for sequence alignment and structural context visualization.
Main Results:
- CATH+ v4.2 increases fully classified domains by over 40% (to 434,857) and predicted domains by nearly two-fold (to over 95 million).
- Coverage of PDB chains with assigned CATH domains increased to 90.2%.
- New web features include sequence-to-FunFam alignment and multi-domain architecture visualization.
Conclusions:
- The CATH database continues to expand its coverage of protein structural and functional data.
- Recent updates enhance usability and provide deeper insights into protein domain relationships and architecture.
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