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[Protein C, protein S].

M C Guillin, A Bezeaud

    Annales De Biologie Clinique
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Protein C is a key anticoagulant and profibrinolytic protein. Deficiencies in Protein C or its cofactor Protein S increase thrombosis risk, impacting coagulation and fibrinolysis.

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    Area of Science:

    • Biochemistry
    • Hematology

    Context:

    • Protein C is a vital anticoagulant and profibrinolytic enzyme.
    • Its activation requires a complex of thrombin and thrombomodulin.
    • Protein S acts as a cofactor, enhancing activated Protein C's function.

    Purpose:

    • To elucidate the anticoagulant and profibrinolytic mechanisms of Protein C.
    • To describe the role of Protein S in Protein C activity.
    • To outline the clinical implications of Protein C and Protein S deficiencies.

    Summary:

    • Activated Protein C (APC) inhibits coagulation factors Va and VIIIa via proteolysis.
    • APC requires phospholipids and Protein S for optimal anticoagulant activity.
    • APC also promotes fibrinolysis by inactivating the tissue plasminogen activator inhibitor.

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    Impact:

    • Protein C and Protein S deficiencies, both inherited and acquired, elevate thrombosis risk.
    • Homozygous deficiency causes neonatal purpura fulminans; heterozygous deficiency leads to recurrent venous thrombosis.
    • Acquired deficiencies are linked to liver disease, certain treatments, and disseminated intravascular coagulation.