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Bone Structure01:55

Bone Structure

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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The Hyoid Bone01:12

The Hyoid Bone

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The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
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Spongy Bone01:09

Spongy Bone

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
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Related Experiment Video

Updated: Feb 3, 2026

Models of Bone Metastasis
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Models of Bone Metastasis

Published on: September 4, 2012

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Modeling of Osteoprobe indentation on bone.

Ashraf Idkaidek1, Iwona Jasiuk1

  • 1Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 West Green Street, Urbana, IL 61801, United States.

Journal of the Mechanical Behavior of Biomedical Materials
|November 7, 2018
PubMed
Summary

Computational modeling of the Osteoprobe instrument reveals that bone material strength index (BMSi) is most sensitive to Young's modulus and damage. Friction and tip radius have minimal impact on BMSi measurements.

Keywords:
Bone fractureBone strengthCortical boneFinite element methodOsteoprobeReference Point Indentation

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Area of Science:

  • Biomechanics
  • Biomaterials Science
  • Computational Modeling

Background:

  • Osteoprobe is a novel handheld instrument for in vivo bone strength testing.
  • The Bone Material Strength index (BMSi) is a key output requiring physical interpretation.
  • Understanding factors influencing BMSi is crucial for clinical adoption.

Purpose of the Study:

  • To computationally model Osteoprobe indentation on cortical bone.
  • To elucidate the physical interpretation of the BMSi output.
  • To investigate the influence of experimental and material properties on BMSi.

Main Methods:

  • Axisymmetric finite element analysis of cortical bone indentation.
  • Utilized an isotropic viscoelastic-plastic constitutive law with continuum damage.
  • Validated the computational model against existing experimental data.

Main Results:

  • Young's modulus and damage constant significantly influence BMSi.
  • Friction coefficient and indenter tip radius (below 30 µm) have minor effects.
  • Compressive yield stress and viscosity constant show moderate correlation with BMSi.

Conclusions:

  • Young's modulus and damage are the primary determinants of Osteoprobe BMSi.
  • The computational model provides a basis for understanding BMSi.
  • Further research is needed to support the clinical integration of Osteoprobe.