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Phase-lead controllers are commonly used in various control systems to enhance response speed and stability. Adjusting the brightness on a television screen offers a practical example of phase-lead control. When contrast is enhanced, a phase-lead controller is employed. Mathematically, phase-lead control is identified when the first parameter is smaller than the second.
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Related Experiment Video

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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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A Fluidic Biosensor Based on a Phase-Sensitive Low-Coherence Spectral-Domain Interferometer.

Cuixia Guo1,2, Xiaojie Yang3, Zhiyuan Shen4

  • 1Department of Physics, Tsinghua University, Beijing 100084, China. guo_c_x@163.com.

Sensors (Basel, Switzerland)
|November 8, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a novel fluidic biosensor utilizing spectral-domain low-coherence interferometry for highly sensitive molecular detection. The biosensor achieves picometer-scale thickness sensitivity and rapid response times for monitoring molecular binding events.

Keywords:
fluidicimmunoassayslow-coherence spectral-domain interferometerphase-sensitive

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Area of Science:

  • Biomedical Engineering
  • Optical Sensing
  • Nanotechnology

Background:

  • Accurate and sensitive detection of molecular interactions is crucial for diagnostics and research.
  • Existing biosensing technologies face limitations in sensitivity, response time, or tolerance to environmental variations.

Purpose of the Study:

  • To develop and characterize a phase-sensitive fluidic biosensor with high sensitivity and rapid detection capabilities.
  • To demonstrate the biosensor's ability to monitor specific molecular binding events and determine minimum detectable concentrations.

Main Methods:

  • A fiber optic probe with a common-path interferometric configuration was employed.
  • Spectral-domain low-coherence interferometry was used for phase analysis of interference signals.
  • The biosensor's performance was evaluated using the binding reactions between Protein A and Immunoglobulin G (IgG).

Main Results:

  • The biosensor demonstrated sub-nanometric thickness change detection with picometer-scale sensitivity.
  • A rapid time response of 13.9 ms was achieved.
  • The minimum detectable concentration of IgG was determined to be 0.11 µg/mL, showing tolerance to concentration fluctuations.

Conclusions:

  • The developed phase-sensitive fluidic biosensor offers high sensitivity, rapid response, and robustness for molecular detection.
  • This technology shows promise for real-time monitoring of specific molecular binding and quantitative analysis in biological samples.