C-Peptide and cardiovascular risk factors among young adults in a southern Brazilian cohort
Romildo Luiz Monteiro Andrade1,2,3, Denise P Gigante4, Isabel Oliveira de Oliveira4
1University Hospital Cassiano Antônio de Moraes (HUCAM) of the Federal, University of Espírito Santo (UFES), Vitória-ES, Brazil. rlmandrade@hotmail.com.
Insights
C-Peptide levels in young adults are linked to obesity and cardiometabolic risk factors. These associations persist from age 23 to 30, highlighting C-Peptide
Area of Science:
- Endocrinology
- Cardiovascular Health
- Public Health
Background:
- C-Peptide, a marker of beta-cell function, is associated with insulin resistance and cardiovascular mortality.
- Understanding C-Peptide's role in metabolic cardiovascular risk factors is crucial for early intervention.
Purpose of the Study:
- To evaluate the association between C-Peptide levels and cardiometabolic risk factors in young adults.
- To examine both cross-sectional and longitudinal relationships over time.
Main Methods:
- Analysis of the Pelotas birth cohort in southern Brazil, following individuals since birth.
- C-Peptide levels measured at age 23 and analyzed cross-sectionally and longitudinally at age 30.
- Assessment of associations with metabolic, cardiometabolic, and hemodynamic risk factors, excluding hyperglycemic patients.
Main Results:
- At 23 years, C-Peptide positively correlated with waist circumference, BMI, glycaemia, triglycerides, and C-reactive protein; negatively with HDL cholesterol.
- At 30 years, longitudinal analysis showed persistent associations with BMI, waist circumference, glycated hemoglobin, triglycerides, and C-reactive protein; negative with HDL.
- C-Peptide demonstrated consistent associations with obesity indicators and cardiometabolic risk factors across both time points.
Conclusions:
- C-Peptide is significantly associated with obesity indicators (BMI, waist circumference) in young adults.
- Both cross-sectional and longitudinal data confirm C-Peptide's link to cardiometabolic and inflammatory risk factors.
- Findings underscore C-Peptide's potential as a marker for metabolic health and cardiovascular risk in young populations.
Background:
Proinsulin connecting peptide (C-Peptide) is a marker of the beta-cell function and has been considered a marker of insulin resistance whose evidence suggests were associated with cardiovascular mortality. Our study aims to evaluate the association of C-Peptide with metabolic cardiovascular risk factors among young adults followed since birth in southern Brazil.
Methods:
In 1982, maternity hospital in Pelotas, a southern Brazilian city, were visited daily and all births were identified. Live births whose family lived in the urban area of the city were identified, their mothers interviewed, and these subjects have been prospectively followed. Casual hyperglycemia patients were excluded from analysis. C-Peptide was assessed at 23 years, when transversely analyzed its association with cardiometabolic and hemodynamic risk factors, and longitudinally 30 years of age.
Results:
At age 23, 4297 individuals were evaluated, and C-Peptide was measured in 3.807. In a cross-sectional analysis at 23 years of age, C-Peptide was positively associated with waist circumference, body mass index, glycaemia, triglycerides, and C-reactive protein. The association with HDL cholesterol was negative. In the longitudinal analysis at 30 years, C-Peptide remained associated with BMI, waist circumference, glycated hemoglobin, triglycerides, and C-reactive protein, whereas the association was negative for HDL.
Conclusion:
In the Pelotas birth cohort, the C-Peptide was associated with obesity indicators (waist circumference and BMI) cross-sectional (23 years) and longitudinal (30 years). We also observed cross-sectional and longitudinal associations of C-Peptide with cardiometabolic and inflammatory risk factors.
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