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FADD at the Crossroads between Cancer and Inflammation

Sara Mouasni1, Léa Tourneur1

  • 1Department of Infection, Immunity and Inflammation, Cochin Institute, 75014 Paris, France; INSERM, U1016, Paris, France; CNRS, UMR8104, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France.

Trends in Immunology
|November 8, 2018
PubMed

Insights

Fas-associated death domain (FADD) is a key regulator in cell death, immunity, and cancer. Recent research reveals its diverse roles in various signaling complexes and its regulation through modifications and secretion.

Area of Science:

  • Molecular Biology
  • Immunology
  • Oncology

Background:

  • Fas-associated death domain (FADD) was initially identified as an adaptor for death receptor-mediated apoptosis.
  • FADD has since been implicated in diverse nonapoptotic cellular processes.
  • It plays a crucial role in regulating various signalosome complexes.

Purpose of the Study:

  • To review recent advancements in understanding the biological roles of FADD.
  • To highlight FADD's impact on innate immunity, inflammation, and cancer.
  • To discuss novel regulatory mechanisms of FADD function.

Main Methods:

  • Literature review of recent studies on FADD.
  • Analysis of FADD's involvement in signalosome complexes (necrosome, inflammasome, etc.).
  • Examination of FADD regulation via post-translational modifications and secretion.

Main Results:

  • FADD is a pleiotropic molecule with multiple protein interactions.
  • FADD is integral to innate immunity, inflammation, and cancer development.
  • Post-translational modifications and secretion are key regulatory mechanisms for FADD.

Conclusions:

  • FADD is a critical mediator in apoptosis, immunity, and cancer.
  • Its multifaceted roles extend beyond its initial description.
  • Understanding FADD's regulation is crucial for therapeutic strategies in inflammation and cancer.
Keywords:
Fas-associated death domaincancerinflammationinnate immunitypost-translational modificationssignalosomes

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