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Updated: Feb 2, 2026
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A Mouse Model of Fatigue Induced by Peripheral Irradiation
Published on: March 17, 2017
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Time to abandon single-site irradiation for inducing abscopal effects
1Department of Radiation Oncology, Unit 97, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nature Reviews. Clinical Oncology
|November 8, 2018
Summary
Combining immune-checkpoint inhibition (ICI) with single-site radiotherapy may yield suboptimal results. Comprehensive irradiation of multiple lesions is proposed to enhance clinical outcomes and avoid premature abandonment of this combination therapy.
Area of Science:
- Oncology
- Immunotherapy
- Radiation Oncology
Background:
- Immune-checkpoint inhibition (ICI) response rates are low (15-30%) in advanced cancers.
- The 'abscopal' effect, where irradiating one tumor shrinks others, is being explored with ICI.
- Hundreds of trials investigate single-site radiotherapy with ICI, inspired by a 2012 case report.
Purpose of the Study:
- To review evidence questioning the efficacy of single-site abscopal radiotherapy combined with ICI.
- To propose a new approach for combining radiotherapy and ICI.
- To prevent premature abandonment of combined ICI and radiotherapy.
Main Methods:
- Review of preclinical and clinical evidence.
- Analysis of the biological rationale for abscopal effects.
- Formulation of a perspective on optimal combination strategies.
Main Results:
- Emerging evidence suggests single-site abscopal approach yields suboptimal results.
- The current approach may not fully leverage potential synergy between radiation and ICI.
- A need exists for alternative combination strategies.
Conclusions:
- The single-site abscopal approach for combining radiotherapy and ICI should be reconsidered.
- Comprehensive irradiation of multiple/all lesions is advocated.
- Further research is needed to optimize radiotherapy and ICI combinations for better cancer treatment outcomes.
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