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Chimeric drift in allophenic mice.

C M Warner, J L McIvor, T J Stephens

    Differentiation; Research in Biological Diversity
    |October 20, 1977
    PubMed
    Summary
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    Chimeric drift, a change in immune cell populations, was observed in 33% of allophenic mice. This immune system instability suggests a potential immunological basis for the observed changes in white blood cell composition.

    Area of Science:

    • Immunology
    • Genetics
    • Developmental Biology

    Background:

    • Allophenic mice are valuable models for studying immune system development and stability.
    • Understanding immune cell composition dynamics is crucial for immunological research.

    Purpose of the Study:

    • To investigate the stability of immune cell populations in allophenic mice.
    • To identify and characterize phenomena like chimeric drift and its potential immunological underpinnings.

    Main Methods:

    • Studied immune system composition in 33 allophenic mice across four genetic types.
    • Analyzed peripheral white blood cells, spleen white blood cells, and thymocytes.
    • Monitored changes in parental cell composition over time and at sacrifice.

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    Main Results:

    • Chimeric drift, a significant change in peripheral white blood cell composition, occurred in 33% of mice.
    • Peripheral white blood cell and spleen white blood cell compositions were highly correlated.
    • Discordance between spleen and thymocyte populations was observed in 24% of mice, often linked to prior chimeric drift.

    Conclusions:

    • Chimeric drift represents a dynamic change in immune cell populations within allophenic mice.
    • The correlation between spleen and thymocyte discordance and prior chimeric drift suggests an immunological basis for these shifts.