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Published on: September 14, 2018
Growth of children with food allergies in Singapore
Kok Wee Chong1, Karen Wright1, Anne Goh1
1Allergy Service, Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore 229899.
Insights
Children with food allergies, particularly mixed IgE and non-IgE types, may experience impaired growth. Early nutritional intervention is recommended to support healthy development in these children.
Area of Science:
- Pediatric Allergy and Immunology
- Nutritional Science
- Growth and Development Studies
Background:
- Children with food allergies are known to be at risk for impaired growth.
- This risk has not been extensively studied in South-East Asia.
- Limited data exists on growth patterns in children with food allergies in Singapore.
Purpose of the Study:
- To survey the growth of children diagnosed with food allergies in Singapore.
- To identify factors impacting growth in this pediatric population.
- To establish baseline growth data for food-allergic children in the region.
Main Methods:
- Cross-sectional study design.
- Collection of anthropometric, demographic, and clinical data (allergy type, excluded foods, comorbidities).
- Malnutrition defined using WHO standards (z-scores for weight-for-height, weight-for-age, height-for-age).
Main Results:
- 74 children (median age 25 months) with food allergies were studied.
- Mixed IgE and non-IgE food allergies were significantly associated with lower weight-for-age (p=0.023).
- Stunting (height-for-age ≤ -2 z-score) was linked to eczema and mixed-type allergies (p=0.002).
- Children with mixed allergies were significantly shorter (z-score -1).
- Skin involvement correlated with lower weight-for-age.
Conclusions:
- This is the first survey on growth in children with food allergy in Singapore.
- Eczema and IgE-mediated or mixed-type allergies are associated with poorer growth.
- Individualized nutritional intervention is recommended for all food-allergic children.
Background:
Although it is known that children with food allergies are at risk of impaired growth, this has not been well studied in South-East Asia.
Objective:
The aim of this cross-sectional study is to survey the growth of children with food allergies in Singapore and the factors impacting it.
Methods:
Anthropometric data, demographic data, type of food allergy, foods eliminated, and atopic comorbidities were recorded. Malnutrition was defined using World Health Organization standards (≤-2 z-score for weight-for-height [WH], weight-for-age [WA], and height-for-age [HA]).
Results:
Seventy-four patients (51% male) were recruited over 1 month, with median age at diagnosis of 8 months (interquartile range [IQR], 4-13 months) and at data collection of 25 months (IQR, 14-48 months). Sixty-two (84%) had IgE-mediated allergy, 8 (11%) mixed IgE and non-IgE, and 4 (5%) non-IgE-mediated allergy. Food exclusions: 55% one food, 27% two foods, 8% three to four foods, and 10% ≥5 foods. Only 1% were underweight (WA ≤ -2 z-score) and 3% had WA ≥ +2 z-score. Having a mixed type food allergy significantly reduced WA (p = 0.023). WA was significantly lower for those referred to the dietitian (p = 0.027). 5.4% were stunted (HA ≤ -2 z-score). Factors significantly associated with stunting were underlying eczema (p = 0.03) and having an IgE-mediated (p = 0.03) or mixed type food allergy (p = 0.002). One point four percent (1.4%) were undernourished (WH ≤ -2 z-score) and 1.4% were overweight (WH ≥ +2 z-score). Multivariate regression analysis found that children with mixed type food allergies were significantly shorter (z-score -1 lower). Children had a lower WA if they had skin involvement as part of their symptom presentation.
Conclusion:
This is the first survey documenting growth in children with food allergy in Singapore. Eczema, IgE-mediated and mixed type allergies are associated with poorer growth rates in these children. Early, individualised nutritional intervention is recommended for all children with food allergy.
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