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Updated: Feb 2, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
[Arterial hypertension in old age with the focus on 80]
Dhayana Dallmeier1,2, Michael D Denkinger3,4
1Geriatrie der Universität Ulm, AGAPLESION Bethesda Klinik, Zollernring 26, 89073, Ulm, Deutschland.
Insights
High blood pressure in older adults increases risks for stroke and heart failure. Guidelines recommend tailored treatment targets, often below 150/70 mmHg, considering frailty and other conditions.
Area of Science:
- Gerontology
- Cardiology
- Internal Medicine
Background:
- Untreated hypertension in older adults elevates risks for secondary conditions like stroke, myocardial infarction, and heart failure.
- Current guidelines offer varying treatment targets based on age and frailty, necessitating careful consideration.
Purpose of the Study:
- To review and synthesize current guidelines for managing hypertension in the elderly.
- To provide recommendations for individualized treatment targets and medication selection in older adults with arterial hypertension.
Main Methods:
- Literature review of current European guidelines on hypertension management in older adults.
- Analysis of treatment recommendations for different frailty levels and age groups.
- Consideration of polypharmacy and multimorbidity in treatment selection.
Main Results:
- For slightly frail individuals up to 80 years, a target systolic blood pressure of 130-139 mmHg is recommended.
- For those over 80, the same target is suggested, but treatment initiation is advised at ≥160 mmHg systolic.
- For physically disabled or very frail individuals, a tailored approach with a target systolic value <150 mmHg (but not below 130/70 mmHg) is recommended.
Conclusions:
- Arterial hypertension in old age can often be managed effectively following guidelines, with individualized approaches for frail patients.
- Careful selection of antihypertensive medications is crucial, considering polypharmacy and potential drug interactions.
- Treatment should be adapted based on patient tolerance and specific clinical circumstances.
Abstract:
Untreated high blood pressure in old age increases the risk of secondary diseases, especially stroke, coronary heart disease, myocardial infarction and heart failure and should be treated according to the guidelines. For slightly frail people up to the age of 80 years, a systolic blood pressure of 130-139 mm Hg (measured in the doctors surgery) should be the aim. According to the current European guidelines the same values are recommended for those over the age of 80 years but treatment should start at a systolic blood pressure of ≥160 mm Hg. In physically disabled and very frail older people an individually tailored approach is recommended, regardless of age. The authors recommend a target systolic value <150 mm Hg but not below 130/70 mm Hg. In the event of poor tolerance the treatment should be adapted further as necessary. Antihypertensive medication should be selected under the aspects of polypharmacy. In many cases arterial hypertension in old age can be treated in accordance with the guidelines, taking multimorbidity and the interaction of medications into consideration.
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