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Related Experiment Video

Updated: Feb 2, 2026

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
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3D Printed Paper-Based Microfluidic Analytical Devices.

Yong He1,2,3, Qing Gao4,5, Wen-Bin Wu6,7

  • 1State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China. yongqin@zju.edu.cn.

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|November 9, 2018
PubMed
Summary

This study introduces a novel, low-cost paper-based microfluidic analytical device (μPAD) fabricated using 3D printing. It utilizes cellulose powder for programmable capillary flow, enabling advanced analytical sequences for point-of-care applications.

Keywords:
3D printingflow speed programmingpaper-based microfluidic analytical devices (μPADs)

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Microfluidics

Background:

  • Paper-based microfluidic analytical devices (μPADs) offer pump-free, lightweight analytical capabilities.
  • Programming the flow speed in μPADs is crucial for designing complex analytical sequences and enhancing their utility.

Purpose of the Study:

  • To develop a novel μPAD with easy fabrication and programmable flow speed.
  • To demonstrate the device's capability in quantitative analysis and sensor fabrication.

Main Methods:

  • Fabrication of a 3D printed substrate with microchannels.
  • Sealing microchannels with polydimethylsiloxane (PDMS).
  • Utilizing a cellulose powder and deionized water mixture to drive capillary flow, with channel depth controlling flow speed.

Main Results:

  • Demonstrated programmable capillary flow speed by varying microchannel depths.
  • Successfully performed quantitative analysis of nitrite ions.
  • Fabricated a T-sensor to showcase the device's versatility.

Conclusions:

  • The 3D printed μPAD offers an accessible, low-cost platform for analytical chemistry.
  • Programmable capillary flow enables sophisticated analytical designs.
  • The device shows significant potential for point-of-care (POC) systems and field testing.