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Area of Science:

  • Pathology
  • Toxicology
  • Biotechnology

Background:

  • Microphysiological systems (MPS), also known as organs-on-chips, represent a significant technological advancement.
  • These systems are increasingly relevant to medical and toxicological pathology.
  • Their application in safety assessment is a key area of development.

Purpose of the Study:

  • To provide a minireview of Microphysiological Systems (MPS) for toxicologic pathologists.
  • To discuss the history and potential utility of MPS in safety assessment.
  • To highlight recent progress and focus areas in MPS development.

Main Methods:

  • Literature review of Microphysiological Systems (MPS) history and applications.
  • Analysis of MPS development focus areas and recent advancements.
  • Discussion of the role of MPS in toxicologic pathology and safety assessment.

Main Results:

  • Microphysiological systems (MPS) have a developing history with significant potential in safety assessment.
  • Key focus areas and recent progress in MPS technology are identified.
  • MPS are expected to become integral to the toxicologic pathologist's role.

Conclusions:

  • Microphysiological systems (MPS) are a rapidly advancing technology with substantial implications for pathology.
  • Toxicologic pathologists will likely integrate MPS into their safety assessment workflows.
  • The pharmaceutical, biotechnology, medical device, cosmetic, and agrichemical industries stand to benefit from MPS adoption.