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Updated: Feb 2, 2026

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
Published on: August 2, 2012
Photoresponsive, Water-Soluble Supramolecular Dendronized Polymer with Specific Lysosome-Targetable Bioimaging
Hang Li1, Jie Wu2, Jia-Fu Yin1
1State Key laboratory of Power metallurgy, Central South University, Lushan South Road 932, Yuelu District, Changsha, Hunan, 410083, P. R. China.
Abstract:
A novel photoresponsive, water-soluble supramolecular dendronized polymer (SDP) is prepared through a γ -cyclodextrin (γ -CD)-coumarin host-guest interaction. The supramolecular formation, photoresponsive process, and fluorescence properties are investigated by nuclear magnetic resonance (NMR) techniques and spectrometric measurements. Upon different-wavelength light irradiation, this supramolecular polymer undergoes noncovalent polymer and covalent polymer conversion due to coumarin cycloaddition and cleavage reactions. In addition, SDP for bioimaging in Michigan Cancer Foundation-7 (MCF-7) cells is performed and results show that the obtained SDP has good biocompatibility and is lysosome-targetable. This research enriches the field of supramolecular dendrimers and the photo-stimulation response material may have application prospects in organelle-targeting applications.
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