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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Feb 2, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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Target Therapy in SLE.

Matthias Schneider1

  • 1Policlinic and Hiller Research Unit, UKD, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.

Autoimmunity Reviews
|November 9, 2018
PubMed
Summary

This review discusses target therapy for Systemic Lupus Erythematosus (SLE), shifting from secondary prevention to achieving remission for better patient outcomes. Achieving remission in SLE patients leads to improved survival and quality of life.

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Current Systemic Lupus Erythematosus (SLE) treatment primarily focuses on secondary prevention of organ damage.
  • Established basic management includes antimalarials, bone protection, sun protection, vaccination, and cardiovascular risk reduction.

Purpose of the Study:

  • To review recent advancements in target therapy for Systemic Lupus Erythematosus (SLE).
  • To explore the shift towards a treat-to-target strategy aiming for remission.

Main Methods:

  • Literature review of current developments in SLE target therapy.
  • Analysis of the principles and objectives of intervention in SLE treatment.

Main Results:

  • The new target therapy approach aims for remission, focusing on long-term survival, preventing organ damage, and enhancing quality of life.
Keywords:
RemissionStrategySystemic lupus erythematosusTreat-to-target

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  • Early evidence suggests patients achieving remission experience better outcomes.

    • Conclusions:

    • A treat-to-target strategy for SLE requires further development and evaluation.
    • Achieving remission is a promising goal for improving long-term outcomes in SLE patients.