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Circulating healing (CH) cells expressing BST2 are functionally activated by the injury-regulated systemic factor
Claudia Lo Sicco1, Daniele Reverberi2, Federico Villa3
1Cellular Oncology Laboratory, Department of Experimental Medicine (DIMES), University of Genova, Largo Rosanna Benzi 10, 16132, Genova, Italy.
Researchers identified circulating healing (CH) cells using bone marrow stromal cell antigen 2 (BST2). These BST2-positive CH cells can be activated by injury signals to promote tissue repair.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Tissue Engineering
Background:
- Endogenous progenitor activation is a promising strategy for tissue repair.
- Understanding stem/progenitor cell properties and their interaction with injured environments is crucial for therapeutic development.
Purpose of the Study:
- To identify and characterize a population of circulating progenitors capable of participating in tissue repair.
- To investigate the role of bone marrow stromal cell antigen 2 (BST2) in isolating these progenitor cells.
Main Methods:
- Isolation of circulating progenitors using BST2 as a marker.
- Characterization of BST2-positive circulating healing (CH) cells.
- Assessment of CH cell response to injury signals and hepatocyte growth factor-activator (HGFA).
Main Results:
- BST2 enables the isolation of circulating healing (CH) cells with a distinct signature.
- BST2-positive CH cells originate from bone marrow, indicated by leptin receptor co-expression.
- CH cells respond to bone fracture signals, alter motility gene expression, and are activated by HGFA into a GALERT state for tissue repair.
Conclusions:
- BST2-positive CH cells represent a novel population of circulating progenitors with regenerative potential.
- These findings may lead to new therapeutic strategies for enhancing endogenous regenerative mechanisms.
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