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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
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Structural Imaging in Atypical Parkinsonism.

Beatrice Heim1, Florian Krismer1, Klaus Seppi2

  • 1Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

International Review of Neurobiology
|November 10, 2018
PubMed
Summary
This summary is machine-generated.

Structural MRI provides objective markers for neurodegeneration in atypical parkinsonism. This review explores its use in diagnosing atypical parkinsonian disorders and tracking disease progression over time.

Keywords:
Atypical parkinsonismCorticobasal syndrome/degenerationMRIMultiple system atrophyProgressive supranuclear palsy

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Atypical parkinsonian disorders (APDs) involve neurodegeneration.
  • Accurate diagnosis and monitoring of APDs are clinically significant.
  • Structural MRI offers objective biomarkers for neurodegenerative processes.

Purpose of the Study:

  • To review structural MRI as a diagnostic tool for APDs.
  • To assess structural MRI's utility in tracking longitudinal changes in APDs.

Main Methods:

  • Review of qualitative and quantitative structural MRI studies in APDs.
  • Analysis of MRI-derived parameters reflecting neurodegeneration (e.g., volume, signal, iron deposition).
  • Evaluation of MRI for differential diagnosis and progression assessment.

Main Results:

  • Structural MRI techniques provide objective measures of neurodegeneration in APDs.
  • Regional changes in tissue volume, signal, and iron deposition serve as surrogate markers.
  • Serial MRI assessments can infer disease progression.

Conclusions:

  • Structural MRI enhances diagnostic accuracy in differentiating APDs.
  • Longitudinal MRI-derived parameters offer robust insights into APD progression.