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Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
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Structural Imaging in Atypical Parkinsonism

Beatrice Heim1, Florian Krismer1, Klaus Seppi2

  • 1Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.

International Review of Neurobiology
|November 10, 2018
PubMed

Insights

Structural MRI provides objective markers for neurodegeneration in atypical parkinsonism. This review explores its use in diagnosing atypical parkinsonian disorders and tracking disease progression over time.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Atypical parkinsonian disorders (APDs) involve neurodegeneration.
  • Accurate diagnosis and monitoring of APDs are clinically significant.
  • Structural MRI offers objective biomarkers for neurodegenerative processes.

Purpose of the Study:

  • To review structural MRI as a diagnostic tool for APDs.
  • To assess structural MRI's utility in tracking longitudinal changes in APDs.

Main Methods:

  • Review of qualitative and quantitative structural MRI studies in APDs.
  • Analysis of MRI-derived parameters reflecting neurodegeneration (e.g., volume, signal, iron deposition).
  • Evaluation of MRI for differential diagnosis and progression assessment.

Main Results:

  • Structural MRI techniques provide objective measures of neurodegeneration in APDs.
  • Regional changes in tissue volume, signal, and iron deposition serve as surrogate markers.
  • Serial MRI assessments can infer disease progression.

Conclusions:

  • Structural MRI enhances diagnostic accuracy in differentiating APDs.
  • Longitudinal MRI-derived parameters offer robust insights into APD progression.
Keywords:
Atypical parkinsonismCorticobasal syndrome/degenerationMRIMultiple system atrophyProgressive supranuclear palsy

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