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Propofol infusion-like syndrome in a dog
John M Mallard1, Teresa M Rieser1, Nathan W Peterson1
1Department of Emergency and Critical Care, VCA West Los Angeles Animal Hospital, Los Angeles, California, USA.
The Canadian Veterinary Journal = La Revue Veterinaire Canadienne
|November 10, 2018
Summary
A dog experienced severe adverse effects, including muscle breakdown and heart rhythm issues, after receiving propofol anesthesia. Prompt administration of N-acetylcysteine led to the resolution of these critical complications.
Area of Science:
- Veterinary Anesthesiology
- Toxicology
- Canine Medicine
Background:
- Propofol is a commonly used anesthetic agent in veterinary medicine.
- Mechanical ventilation was required due to the dog's presenting condition (dyspnea).
Observation:
- A Chihuahua mix developed rhabdomyolysis, myoglobinuria, cardiac arrhythmias, elevated liver enzymes, and methemoglobinemia during propofol anesthesia.
- These clinical signs emerged during the anesthetic period.
Findings:
- Discontinuation of propofol was followed by N-acetylcysteine administration.
- Clinical signs resolved after N-acetylcysteine treatment.
Implications:
- This case highlights potential severe adverse effects of propofol in dogs.
- N-acetylcysteine may be a beneficial treatment for propofol-induced toxicity.
- Further investigation into propofol-associated complications in veterinary patients is warranted.
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