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A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
Published on: December 28, 2013
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Normal patterns of regional brain 18F-FDG uptake in normal aging
Sara Pourhassan Shamchi1, Mohsen Khosravi, Raheleh Taghvaei
1Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA. abass.alavi@uphs.upenn.edu.
Hellenic Journal of Nuclear Medicine
|November 10, 2018
Summary
Normal aging significantly reduces brain glucose metabolism, particularly in the supratentorial regions, as shown by fluorine-18 fluorodeoxyglucose (18F-FDG) PET scans. Cerebellar uptake shows less reduction, and females exhibit higher uptake.
Area of Science:
- Neuroscience
- Radiology
- Gerontology
Background:
- Normal aging impacts brain function without apparent structural changes.
- 18F-FDG PET imaging can detect these functional alterations.
- Understanding age-related changes is crucial for diagnosing pathological conditions.
Purpose of the Study:
- To evaluate age-related changes in regional brain 18F-FDG uptake in healthy individuals.
- To establish a baseline for normal aging brain metabolism.
- To differentiate normal aging from disease-related changes.
Main Methods:
- Prospective recruitment of 40 healthy subjects into young (22-32 years) and old (56-75 years) groups.
- 18F-FDG PET/CT scans performed 180 minutes post-injection.
- Manual region of interest placement for supratentorial and cerebellar uptake quantification (SUVmean).
Main Results:
- Significant age-dependent reduction in supratentorial 18F-FDG uptake (P<0.001).
- Reduced uptake observed in frontal, parieto-occipital, and temporal lobes with aging.
- Cerebellar 18F-FDG uptake showed a less pronounced age-related decrease (P=0.028).
- Higher supratentorial 18F-FDG uptake in females across both age groups.
Conclusions:
- Normal aging is associated with a significant decrease in supratentorial brain metabolism.
- Cerebellar metabolism is less affected by normal aging.
- All cerebral lobes demonstrate reduced 18F-FDG uptake with age.
- Females consistently show higher supratentorial 18F-FDG uptake.
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