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Updated: Feb 2, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
The pathology of oral cancer
1School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK.
Abstract:
The term 'oral cancer' describes a range of malignancies that may arise in and around the oral cavity. Over 90% of such lesions are squamous cell carcinomas, but even these may be divided into different entities based on site, aetiology and prognosis. In particular, squamous carcinomas in the oral cavity (oral cancer) should be regarded as a different disease to carcinomas arising in the oropharynx. Oropharyngeal cancer is associated with infection by human papillomavirus (HPV) and shows different clinical and histological features. This short review summarises the pathology of oral and oropharyngeal cancer, and describes some of the main prognostic factors that pathologists use to assist clinicians in planning appropriate management.
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