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Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models
Na Xue1, Xianwei Wu1, Li Wu1
1Department of the Second Anesthesiology, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
Abstract:
Inflammation is the vital defensive response triggered by our immune system against an infection or deleterious stimuli. This response in due course affects its own biological system leading to serious diseases like arteriosclerosis, osteoporosis, pancreatitis, cancer etc. Currently, researchers focused on utilizing phytochemicals as anti-inflammatory drugs since the drugs presently available in the market causes serious side effects and are less potent. Flavonoids are polyphenols which imparts colours to the plants and fruits. These flavonoids serve as phytonutrients to plants and they also possess antioxidant, anti-inflammatory and anti-cancer properties. Naringenin is one such flavonoid classified under flavones groups present in citrus fruits and vegetables. The present study is aimed to identify and confirm the antinociceptive and anti-inflammatory efficacy of Naringenin in different mice models. The antinociceptive effect of Naringenin was analyzed by both thermal induced and chemical induced nociceptive mice models. Carrageenan-induced paw edema test was performed to detect the anti-inflammatory effect of Naringenin and it is confirmed by analyzing the leukocyte infiltration in peritoneal cavity. Air pouch model test is performed to estimate the inhibitory property of Naringenin against proinflammatory cytokines. The potency of drug Naringenin was confirmed by treating along with opioid inhibitors naloxone and the results compared with standard drugs. To assess the muscle relaxant property of Naringenin open field test was performed. The overall results of Naringenin in different nociceptive and inflammatory mice models suggest that, Naringenin is a potent anti-inflammatory drug which relieves pain effectively and can be used in pain management therapy.
Insights
Naringenin, a flavonoid from citrus fruits, demonstrates potent anti-inflammatory and pain-relieving effects in mice models. This natural compound shows promise as an effective alternative for pain management therapy.
Area of Science:
- Pharmacology
- Natural Products Chemistry
Background:
- Inflammation is a critical immune response that can lead to severe diseases.
- Current anti-inflammatory drugs have limitations, driving research into phytochemicals.
- Flavonoids, like Naringenin, are plant compounds with antioxidant and anti-inflammatory properties.
Purpose of the Study:
- To evaluate the antinociceptive (pain-relieving) and anti-inflammatory efficacy of Naringenin.
- To explore Naringenin's potential as a therapeutic agent for pain management.
Main Methods:
- Naringenin's antinociceptive effects were tested using thermal and chemical pain models in mice.
- Anti-inflammatory activity was assessed via carrageenan-induced paw edema and leukocyte infiltration.
- Inhibitory effects on pro-inflammatory cytokines were studied using an air pouch model.
- Muscle relaxant properties were evaluated using the open field test.
Main Results:
- Naringenin exhibited significant antinociceptive effects in various pain models.
- The compound demonstrated potent anti-inflammatory activity, reducing edema and leukocyte infiltration.
- Naringenin showed potential in inhibiting pro-inflammatory cytokines.
- The study confirmed Naringenin's efficacy, comparable to standard drugs, and noted muscle relaxant properties.
Conclusions:
- Naringenin is a potent anti-inflammatory agent with effective pain-relieving capabilities.
- The findings suggest Naringenin's suitability for use in pain management therapies.
- Naringenin represents a promising natural alternative to conventional anti-inflammatory drugs.
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