Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mismatch Repair

Mismatch Repair

Overview of DNA Repair

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...

Base Excision Repair

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...

Nucleotide Excision Repair

Nucleotide Excision Repair

Heart Valves

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ross(-Konno) Procedure in Neonates and Infants: A Multicentre Experience.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026

Same author

Risk stratification for progression to adenocarcinoma and high-grade dysplasia in Barrett's esophagus: a cohort study from an expert Spanish center.

Revista espanola de enfermedades digestivas·2025

Same author

Predicting hepatic decompensation using non-invasive tests in a contemporary multicentre cohort of patients with cACLD.

Journal of hepatology·2025

Same author

Targetable pathways for drug repurposing in gastric cancer.

World journal of gastroenterology·2025

Same author

Familial Non-Hereditary Gastric Cancer: Diagnosis, Management, Molecular Characteristics and Future Perspective.

Cancers·2025

Same author

Enhancing specific thymic Treg activation and function with 4-1BB monomeric streptavidin-based CARs.

Translational research : the journal of laboratory and clinical medicine·2025

Search research articles

Related Experiment Video

Updated: Feb 2, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

Upper Ministernotomy for Pulmonary Valve Repair.

Juan-Miguel Gil-Jaurena¹, Ramón Pérez-Caballero¹, Ana Pita¹

¹Section of Pediatric Cardiac Surgery, Hospital Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Spain.

The Annals of Thoracic Surgery

|November 12, 2018

Summary

This study details a pulmonary valve repair in an adolescent using an upper ministernotomy approach. It highlights surgical techniques for optimal valve visualization during the procedure.

More Related Videos

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve

Published on: August 5, 2021

Related Experiment Videos

Last Updated: Feb 2, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve

Published on: August 5, 2021

Area of Science:

Cardiovascular Surgery
Pediatric Cardiac Surgery
Thoracic Surgery

Background:

Congenital heart defects often necessitate pulmonary valve repair.
Minimally invasive surgical techniques are increasingly favored in pediatric cardiac surgery.
Upper ministernotomy offers a less invasive alternative for cardiac procedures.

Observation:

The case involved a pulmonary valve repair in an adolescent patient.
An upper ministernotomy approach was utilized for surgical access.
Specific surgical field manipulations were employed to improve valve exposure.

Findings:

Successful pulmonary valve repair was achieved in the adolescent.
The upper ministernotomy facilitated adequate surgical access to the pulmonary valve.
The depicted techniques enhanced intraoperative visualization of the pulmonary valve.

Implications:

Upper ministernotomy is a viable approach for pulmonary valve repair in adolescents.
Improved visualization techniques can enhance surgical outcomes in pediatric cardiac procedures.
This approach may reduce surgical trauma and improve recovery times for young patients.