Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

907
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
907
What are Viruses?00:50

What are Viruses?

128.2K
Overview
128.2K
Drug Discovery: Overview01:26

Drug Discovery: Overview

11.6K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
11.6K
RNA Interference01:23

RNA Interference

28.1K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.1K
RNA Structure01:23

RNA Structure

79.1K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.1K
RNA Stability01:53

RNA Stability

35.7K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RdRpCATCH: a unified resource for RNA virus discovery using viral RNA-dependent RNA polymerase profile Hidden Markov models.

NAR genomics and bioinformatics·2026
Same author

Comprehensive hallmark gene sequence, genomic and structural analysis clarifies new and established taxa within the <i>Picornavirales</i>.

Virus evolution·2026
Same author

The dynamics and strategy of RNA replication in astroviruses.

NAR molecular medicine·2026
Same author

Anthropozoonotic spillovers reveal sustained long-term cryptic circulation of SARS-CoV-2 within and between Lithuanian mink farms.

Virus evolution·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Uncovering hundreds of exogenous and endogenous RNA viral RdRp sequences amongst uncharacterized sequences in public protein databases.

Virus evolution·2025

Related Experiment Video

Updated: Feb 2, 2026

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

766

Discovery of three RNA viruses using ant transcriptomic datasets.

Eleni Kleanthous1, Ingrida Olendraite1, Nina I Lukhovitskaya1

  • 1Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.

Archives of Virology
|November 12, 2018
PubMed
Summary

Three new RNA viruses were discovered in UK ants: Formica fusca virus 1, Lasius neglectus virus 2, and Myrmica scabrinodis virus 2. Phylogenetic analysis placed them in distinct viral families, showing high divergence from known viruses.

More Related Videos

Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing
08:58

Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing

Published on: August 1, 2025

3.1K
Zika Virus Specific Diagnostic Epitope Discovery
11:37

Zika Virus Specific Diagnostic Epitope Discovery

Published on: December 12, 2017

8.3K

Related Experiment Videos

Last Updated: Feb 2, 2026

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

766
Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing
08:58

Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing

Published on: August 1, 2025

3.1K
Zika Virus Specific Diagnostic Epitope Discovery
11:37

Zika Virus Specific Diagnostic Epitope Discovery

Published on: December 12, 2017

8.3K

Area of Science:

  • Virology
  • Entomology
  • Genomics

Background:

  • Ants are important model organisms in ecological and evolutionary studies.
  • Insect-borne viruses play significant roles in host population dynamics and evolution.
  • Limited knowledge exists on the virome of common ant species.

Purpose of the Study:

  • To discover and characterize novel RNA viruses in ant populations.
  • To determine the phylogenetic relationships of newly identified ant viruses.
  • To expand the understanding of viral diversity within Hymenoptera.

Main Methods:

  • High-throughput RNA sequencing of ant samples.
  • De novo transcriptome assembly for genome sequence retrieval.
  • Sanger sequencing for confirmation of viral genomes.
  • Phylogenetic analysis using established bioinformatics pipelines.

Main Results:

  • Discovery of three novel RNA viruses: Formica fusca virus 1 (Nyamiviridae), Lasius neglectus virus 2 (Rhabdoviridae), and Myrmica scabrinodis virus 2 (Dicistroviridae).
  • Genome sequences were obtained and confirmed for all three viruses.
  • Phylogenetic analyses revealed significant divergence from previously characterized viruses within their respective families.
  • Formica fusca virus 1, Lasius neglectus virus 2, and Myrmica scabrinodis virus 2 represent new species or genera.

Conclusions:

  • The study expands the known diversity of RNA viruses in ants.
  • The identified viruses belong to three different established viral families, indicating diverse evolutionary origins.
  • These findings highlight the potential for discovering novel viruses in understudied insect populations.