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Related Experiment Videos

Acyclovir crystalluria.

N A Peterslund1, M L Larsen, H Mygind

  • 1Department of Medicine, Marselisborg Hospital, Aarhus, Denmark.

Scandinavian Journal of Infectious Diseases
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Acyclovir crystals in urine, though rare, may signal kidney damage. This study found no crystalluria in patients receiving oral or IV acyclovir, suggesting it could be an early indicator of nephropathy.

Area of Science:

  • Nephrology
  • Pharmacology
  • Virology

Background:

  • Acyclovir is a crucial antiviral medication used to treat herpes virus infections.
  • Intravenous administration of acyclovir is typically reserved for severe cases like herpes encephalitis.

Observation:

  • A case report detailed acyclovir crystalluria and renal tubular impairment in a patient receiving intravenous acyclovir.
  • Urinary beta-2-microglobulin levels were elevated, indicating renal tubule dysfunction.

Findings:

  • A subsequent study of 80 patients (60 oral, 20 IV acyclovir) found no instances of acyclovir crystalluria.
  • No patients in the study exhibited elevated serum creatinine levels, a common marker for kidney injury.

Implications:

Related Experiment Videos

  • Acyclovir crystalluria may serve as an early warning sign for acyclovir-induced nephropathy.
  • The low incidence in the studied cohort suggests crystalluria is not a common side effect of standard acyclovir treatment regimens.