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Doppler Optical Coherence Tomography of Retinal Circulation
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Improved speckle contrast optical coherence tomography angiography.

Liwei Wang1, Yuejie Li1, Yilu Li1

  • 1Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 300192, China.

American Journal of Translational Research
|November 13, 2018
PubMed
Summary

An improved speckle contrast optical coherence tomography angiography (ISC-OCTA) algorithm effectively visualizes microvasculature in vivo. This novel method suppresses motion artifacts, enhancing diagnostic capabilities for ophthalmic diseases.

Keywords:
Optical coherence tomographyblood vesselsmicrocirculationoptical coherence tomography angiographyspeckle contrast

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Area of Science:

  • Ophthalmic imaging
  • Biomedical optics
  • Medical diagnostics

Background:

  • Optical coherence tomography angiography (OCTA) visualizes biological tissue vasculature.
  • Existing OCTA methods struggle with motion artifacts, particularly in retinal imaging.
  • Accurate microvasculature imaging is crucial for diagnosing ophthalmic conditions.

Purpose of the Study:

  • To introduce an improved speckle contrast optical coherence tomography angiography (ISC-OCTA) algorithm.
  • To overcome limitations of current OCTA techniques, specifically bulk motion noise.
  • To enhance visualization of the vasculature network in vivo.

Main Methods:

  • Developed an improved speckle contrast algorithm using N consecutive frames.
  • Acquired improved speckle contrast images for vasculature imaging.
  • Masked averaged images with improved speckle contrast images to generate vasculature maps.
  • Tested ISC-OCTA on in vivo mouse ear and human macula images.

Main Results:

  • ISC-OCTA successfully distinguished blood flow dynamics from static tissue.
  • Capillary vessels were clearly visualized.
  • The algorithm demonstrated significant suppression of line noise, especially when segmentation data was compromised.
  • Performance was comparable to existing algorithms but with superior motion artifact reduction.

Conclusions:

  • ISC-OCTA provides clear and reliable visualization of vasculature in vivo.
  • The algorithm effectively mitigates motion artifacts, improving image quality.
  • ISC-OCTA shows potential for improved diagnosis of ophthalmic diseases.