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Updated: Feb 2, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
Routine replacement of a vagal nerve stimulator generator leading to asystole
Keith Conti1, Steven M Falowski2
1St. Luke's School of Medicine, 801 Ostrum St, Bethlehem, PA, USA 18015.
Abstract:
A 52-year-old female with a longstanding history of drug-resistant epilepsy that included focal impaired awareness seizure presented at end of service of her vagus nerve stimulator (VNS) generator. She had undergone a generator replacement in 2010 without complication. However, her latest replacement was accompanied by multiple bouts of asystole. We discuss the case, possible causes of the asystole, and its relevance to the future of VNS generator replacement and epilepsy treatment.
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