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The Structure and Biological Function of CREG
Gaby Ghobrial1, Luiz Araujo1, Felecia Jinwala1
1Department of Surgery, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, United States.
Frontiers in Cell and Developmental Biology
|November 13, 2018
Summary
Cellular repressor of E1A-stimulated genes (CREG) is vital for development and metabolism. This review explores CREG
Area of Science:
- Biochemistry
- Molecular Biology
- Developmental Biology
Background:
- Cellular repressor of E1A-stimulated genes (CREG) is a glycoprotein lacking enzymatic activity.
- CREG is primarily intracellular, localized in the endocytic-lysosomal compartment, and undergoes proteolytic maturation.
- CREG interacts with mannose-6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R) and exocyst Sec8.
Purpose of the Study:
- To review the known biochemistry and biology of CREG.
- To highlight essential roles of CREG in development and metabolism.
- To identify future research questions regarding CREG.
Main Methods:
- Biochemical interaction studies.
- Cellular overexpression and knockdown experiments.
- Genetic knockout studies in Drosophila and mice.
Main Results:
- CREG overexpression inhibits cell proliferation and induces differentiation and senescence.
- CREG deficiency causes developmental lethality in Drosophila and embryonic death in mice.
- CREG1 deficiency in mice leads to obesity, hepatic steatosis, and insulin resistance.
Conclusions:
- CREG plays a critical role in embryonic development.
- CREG is essential for maintaining metabolic homeostasis.
- Further research is needed to fully elucidate CREG's functions and therapeutic potential.
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