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Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
Relationship between current smoking, visual CT findings and emphysema index in cigarette smokers
Sung Shick Jou1, Kunihiro Yagihashi2, Jordan Alexander Zach3
1Department of Radiology, Soonchunhyang University Cheonan Hospital, 31 Soonchunhyang 6-gil, Dongnamgu, Cheonan-si, Chungchengnam-do 311511, Republic of Korea.
Purpose:
To evaluate whether visual CT findings could account for the effect of current smoking.
Methods:
500 CT scans were visually evaluated within each lobe. A multivariate model for emphysema index was constructed containing previously described confounders in addition to the visual components associated with smoking status.
Results:
Current smokers displayed 23% less visual emphysema, 19% more airway wall thickening, and 188% more centrilogular nodule than former smokers (all p < 0.001). The effect of current smoking on the emphysema index decreased after adjustment with confounders and visual parameters.
Conclusions:
Visual CT findings could partially account for the effect of current smoking.
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