Related Experiment Video
Updated: Feb 2, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
[Update - Lithium in the Long-Term Treatment of Bipolar Disorders]
Johannes Petzold1, Michael Bauer1, Emanuel Severus1
1Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Psychiatrie und Psychotherapie.
Abstract:
Lithium is the gold standard in the long-term treatment of bipolar disorders and the only substance with a convincing antisuicidal effect in affective disorders. Under regular monitoring, lithium represents mostly a well-tolerated and safe medication. Balancing risk and benefits shows that lithium can also be an off-label therapeutic option during pregnancy and breast feeding. Lithium may exhibit neuroprotective effects and has been linked to a reduced risk of Alzheimer's disease and stroke. In the future, biomarkers of lithium response may be available that enable development of more personalized therapies.
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