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Neurotheranostics as personalized medicines.
Bhavesh D Kevadiya1, Brendan M Ottemann1, Midhun Ben Thomas1
1Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Neurotheranostics, combining diagnostics and therapeutics for neurological disorders, face formulation challenges. Multidisciplinary teams aim to overcome these for personalized medicine in neurodegenerative, neuroinflammatory, and neuroinfectious diseases.
Area of Science:
- Neuroscience
- Pharmacology
- Nanotechnology
- Pharmaceutics
Background:
- Neurotheranostics aims to enhance diagnostic and therapeutic outcomes for neurological disorders.
- Multimodal pharmaceutical formulations are key to advancing neurotheranostic research.
- Current challenges include formulation design, drug loading, and payload delivery.
Purpose of the Study:
- To review the current state of neurotheranostics.
- To explore the potential of neurotheranostic agents in revolutionizing disease staging and treatment.
- To identify how neurotheranostics can be applied as personalized medicine for various neurological diseases.
Main Methods:
- Review of extensive literature on the natural history, epidemiology, pathogenesis, and therapeutics of neurological diseases.
- Analysis of the role of multimodal pharmaceutical formulations in neurotheranostics.
- Exploration of multidisciplinary approaches involving pharmacology, nanotechnology, neuroscience, and pharmaceutics.
Main Results:
- Neurotheranostic agents hold significant potential for improving nervous system disease outcomes.
- Overcoming formulation and delivery obstacles is crucial for successful neurotheranostic deployment.
- Multidisciplinary collaboration is essential for developing optimal therapeutic delivery platforms.
Conclusions:
- Neurotheranostics are poised to become personalized medicines for a wide range of neurological conditions.
- Successful neurotheranostic development requires integrated expertise from diverse scientific fields.
- Continued research is needed to fully realize the potential of neurotheranostics in clinical practice.
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