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Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Related Experiment Video

Updated: Feb 2, 2026

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

Published on: October 18, 2024

Obesity: When to consider surgery.

Sarah R Barenbaum¹, Katherine H Saunders², Leon I Igel²

¹Department of Internal Medicine, New York-Presbyterian Hospital/Weill Cornell Medical College, New York, NY, USA.

The Journal of Family Practice

|November 14, 2018

Summary

This summary is machine-generated.

Bariatric surgery is often overlooked for obesity management. This study highlights its use in 3 patients who achieved weight and health goals after nonsurgical methods failed.

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Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Area of Science:

Metabolic and Bariatric Surgery
Obesity Medicine
Patient Case Studies

Background:

The global obesity epidemic necessitates effective, accessible weight management solutions.
Nonsurgical interventions frequently fail to achieve sustained weight loss and health improvements for many individuals.
Bariatric surgery remains underutilized despite its proven efficacy in treating severe obesity.

Observation:

Three patients with obesity were evaluated for bariatric surgery.
These patients had previously attempted and failed to reach target weight and optimal health through nonsurgical means.
The decision for surgical intervention was based on the limitations of conservative treatments.

Findings:

Bariatric surgery was pursued as a viable option for these patients.
The study focuses on the patient journey towards surgical consideration when other methods are insufficient.
This case series underscores the role of surgery in comprehensive obesity management.

Implications:

Increased utilization of bariatric surgery could address the obesity epidemic more effectively.
Further research is needed to understand barriers to bariatric surgery access.
Personalized treatment strategies, including surgical options, are crucial for improving patient outcomes in obesity care.