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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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Antagonism of adenosinergic system decrease SWD occurrence via an increment in thalamic NFkB and IL-6 in absence
Fazilet Dede1, Sabriye Karadenizli1, Ozgur Doga Ozsoy2
1Department of Physiology, Medical Faculty of Kocaeli University, Kocaeli, Turkey.
Journal of Neuroimmunology
|November 14, 2018
Summary
Caffeine reduced absence seizures in WAG/Rij rats by decreasing spike-wave discharge (SWD) and increasing thalamic NFkB and IL-6. Adenosine did not affect seizures or inflammation, suggesting a role for the adenosinergic system in absence epilepsy.
Area of Science:
- Neuroscience
- Pharmacology
- Immunology
Background:
- Epilepsy affects 1% of the population, with known links to inflammation.
- The adenosinergic system modulates neurotransmitter release, influencing both inflammation and epilepsy.
- The WAG/Rij rat strain serves as a genetic model for absence epilepsy.
Purpose of the Study:
- To investigate the impact of adenosinergic system agonists and antagonists on seizure activity.
- To analyze changes in cytokine levels in response to adenosinergic system modulation.
- To explore the relationship between inflammation markers and absence epilepsy in WAG/Rij rats.
Main Methods:
- WAG/Rij rats were administered saline, Tween 20, adenosine, or caffeine.
- Electroencephalography (EEG) was used to record seizure activity (spike-wave discharges).
- Enzyme-linked immunosorbent assay (ELISA) measured cytokine levels (NFkB, TNF-α, IL-1β, IL-6) in brain tissue and blood.
Main Results:
- Caffeine administration led to a significant reduction in spike-wave discharge (SWD) frequency.
- Caffeine increased levels of NFkB and IL-6 in the thalamus.
- Adenosine administration did not significantly alter seizure activity or cytokine levels.
Conclusions:
- Increased thalamic IL-6 and NFkB levels correlate with reduced absence epilepsy.
- The adenosinergic system plays a role in absence seizures in WAG/Rij rats.
- The thalamus is crucial for the occurrence of SWDs within the thalamocortical loop.
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