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Updated: Feb 2, 2026
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Three-dimensional Optical-resolution Photoacoustic Microscopy
Published on: May 3, 2011
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Miniaturized Optical Resolution Photoacoustic Microscope Based on a Microelectromechanical Systems Scanning Mirror
Weizhi Qi1,2, Qian Chen3,4, Heng Guo5,6
1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China. qiweizhi@std.uestc.edu.cn.
Micromachines
|November 15, 2018
Summary
A new miniaturized photoacoustic microscopy system uses a microelectromechanical system (MEMS) scanning mirror for high-resolution imaging. This compact device shows potential for biological and clinical applications, including in vivo vasculature imaging.
Area of Science:
- Biomedical Optics
- Microscopy
- Photoacoustic Imaging
Background:
- Photoacoustic microscopy (PAM) offers high resolution and contrast for biological tissue imaging.
- Existing PAM systems can be bulky and complex, limiting their field applications.
- Miniaturization is key for developing portable and versatile imaging tools.
Purpose of the Study:
- To develop and evaluate a miniaturized optical resolution photoacoustic microscopy (OR-PAM) system.
- To utilize a microelectromechanical system (MEMS) scanning mirror for OR-PAM.
- To demonstrate the system's capability for in vivo biological imaging.
Main Methods:
- A 2D MEMS scanning mirror was integrated for raster scanning of the excitation optical focus.
- Wideband photoacoustic signals were detected using a 10 MHz flat ultrasound transducer.
- The system's dimensions and weight were measured at 60 mm × 30 mm × 20 mm and 40 g.
Main Results:
- The system successfully imaged microstructures like sharp blades, carbon fibers, and a silver strip.
- In vivo imaging of mouse ear and brain vasculature was achieved.
- Human lip vasculature was also successfully imaged, demonstrating clinical applicability.
Conclusions:
- The developed MEMS-based OR-PAM system is highly miniaturized and portable.
- The system provides high-resolution imaging of biological tissues.
- This technology holds significant promise for preclinical research and clinical diagnostics.
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