Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Non-ohmic Devices00:51

Non-ohmic Devices

1.5K
In most substances, the current flow is proportional to the voltage applied to it. A simple relationship between the values of current, voltage, and resistance is known as Ohm's law. Nonohmic devices do not exhibit a linear relationship between voltage and current. One such device is the semiconducting circuit element known as a diode. A diode is a circuit device that allows current flow in only one direction.
Consider a simple circuit consisting of a battery, a diode, and a resistor. A...
1.5K
Mnemonic Devices01:23

Mnemonic Devices

432
Mnemonic devices are cognitive tools that facilitate memory retention by linking new information to familiar patterns or organizational strategies. These techniques are beneficial for remembering complex or lengthy sets of information by simplifying and structuring them in easily retrievable ways.
Acronyms
Acronyms are created by using the initial letters of a series of words to form a new word or phrase. This approach condenses complex information into a single, memorable entity. For example,...
432
DC Generator01:19

DC Generator

2.1K
An alternator converts mechanical energy into electrical energy that varies sinusoidally, resulting in AC current. Meanwhile, a DC generator converts mechanical energy into electrical energy, which are DC pulses with the same polarity. The construction of a DC generator is similar to that of an alternator, except that the pair of slip rings is replaced by a single split ring, also called a commutator. The commutator functions like a periodic rotary switch; it changes the contacts with the...
2.1K
Next-generation Sequencing03:00

Next-generation Sequencing

98.5K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
98.5K
Generation Time01:22

Generation Time

1.5K
Bacterial generation time, the period required for a bacterial population to double during its exponential growth phase, serves as a critical measure of microbial growth dynamics under optimal conditions. This parameter varies significantly across bacterial species and can be influenced by factors such as temperature, pH, and the availability of nutrients. For example, Escherichia coli can achieve a generation time of approximately 20 minutes, while Mycobacterium tuberculosis exhibits a much...
1.5K
Strong Acid and Base Solutions03:22

Strong Acid and Base Solutions

35.7K
A strong acid is a compound that dissociates completely in an aqueous solution and produces a concentration of hydronium ions equal to the initial concentration of acid. For example, 0.20 M hydrobromic acid will dissociate completely in water and produces 0.20 M of hydronium ions and 0.20 M of bromide ions.
35.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comprehensive benchmark of multi-generation YOLO architectures for forest species identification from macroscopic wood images.

Scientific reports·2026
Same author

Effects of Au Nanoparticles Suspended in Chlorobenzene Antisolvent on Mixed-Halide Perovskites.

ACS omega·2025
Same author

Expression of concern: A hysteresis-free perovskite transistor with exceptional stability through molecular cross-linking and amine-based surface passivation.

Nanoscale·2025
Same author

Impact of Genetic Polymorphisms on Electrochemical Parameters and Acid-Base Disorders in Brazilian Runners During a 105-Kilometer Ultramarathon.

Nutrients·2024
Same author

Effect of Temperature, Pressure, and Type of Gas Injected on the Formation and Decay of Mineral Oil-Based Foams.

ACS omega·2023
Same author

Genetic Polymorphisms and Their Impact on Body Composition and Performance of Brazilians in a 105 Km Mountain Ultramarathon.

European journal of investigation in health, psychology and education·2023

Related Experiment Video

Updated: Feb 2, 2026

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.8K

Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation.

Carlos Toshiyuki Matsumi1, Wilson José da Silva2, Fábio Kurt Schneider3

  • 1Department of Electronics, Federal Institute of Education, Science and Technology of Santa Catarina (IFSC), Joinville, SC 89220-618, Brazil. matsumi@ifsc.edu.br.

Micromachines
|November 15, 2018
PubMed
Summary

This study introduces a low-cost, hybrid method using 3D printing and micropipettes to create monodisperse microbubbles. This technique simplifies microbubble generation for applications in drug delivery and medical imaging.

Keywords:
3D printing microfluidic devicescross-flowmicrobubblesmicropipettes

More Related Videos

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.6K
Thermal Measurement Techniques in Analytical Microfluidic Devices
08:29

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

10.1K

Related Experiment Videos

Last Updated: Feb 2, 2026

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.8K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.6K
Thermal Measurement Techniques in Analytical Microfluidic Devices
08:29

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

10.1K

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Materials Science

Background:

  • Microbubbles are crucial for targeted drug/gene delivery and medical diagnostic imaging.
  • Existing microbubble production methods (e.g., CEHDA, sonication, microfluidics) can be complex, costly, or require stringent safety measures.
  • There is a need for simpler, more accessible methods for generating monodisperse microbubbles.

Purpose of the Study:

  • To develop a hybrid manufacturing process for generating monodisperse microbubbles.
  • To create a simple, low-cost T-Junction microfluidic device for microbubble production.
  • To characterize the size and polydispersity of the generated microbubbles.

Main Methods:

  • A hybrid manufacturing approach combining 3D printing and micropipettes to construct a T-Junction microfluidic device.
  • Fabrication of microfluidic devices using readily available materials and techniques.
  • Systematic generation and characterization of microbubbles, measuring average size and polydispersity index (PDI).

Main Results:

  • Successfully generated microbubbles with average sizes ranging from 16.6 to 57.7 μm and low PDI (0.47%–1.06%).
  • At higher production rates, average diameter was 42.8 μm with a PDI of 3.13%.
  • Developed a predictive model (second-order polynomial) for estimating micropipette diameter and identified a linear relationship between flow rate ratios and diameter ratios.

Conclusions:

  • The hybrid 3D printing and micropipette method offers a simple and cost-effective approach for producing monodisperse microbubbles.
  • The developed microfluidic device is suitable for controlled microbubble generation.
  • The established characteristic curves and relationships facilitate precise control over microbubble size for various applications.