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Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
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Aging and drug discovery.

Daniela Bakula1, Alexander M Aliper2, Polina Mamoshina2

  • 1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

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Researchers are exploring molecules to extend healthspan and target age-associated diseases. A consensus is emerging that interventions in the aging process could transform healthcare and society.

Keywords:
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Area of Science:

  • Gerontology
  • Drug Discovery
  • Biotechnology

Background:

  • Interventions extending healthspan in model organisms are known.
  • Industry and academia are investigating molecules targeting aging and age-related diseases.

Purpose of the Study:

  • Summarize discussions from the 5th Annual Aging and Drug Discovery Forum 2018.
  • Highlight progress and challenges in aging research and drug discovery.

Main Methods:

  • Review of talks and discussions from the 2018 Aging and Drug Discovery Forum.
  • Synthesis of key themes including aging mechanisms, biomarkers, interventions, and AI applications.

Main Results:

  • Aging mechanisms, conserved longevity signatures, and emerging biomarkers were discussed.
  • Potential interventions and the role of artificial intelligence in aging research were explored.
  • A consensus on the transformative potential of aging intervention molecules is emerging.

Conclusions:

  • Molecules targeting the aging process hold significant potential for transforming healthcare.
  • Collaboration between academia and industry is crucial for advancing aging research and drug discovery.