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Antibiotic Selection00:57

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Selection inversion: a probable tool against antibiotic resistance.

Zulqarnain Baloch1, Bilal Aslam2, Saima Muzammil2

  • 1College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Infection and Drug Resistance
|November 15, 2018
PubMed
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Antibiotic resistance is a growing problem. New strategies could leverage how resistance to one drug affects sensitivity to others, potentially reversing resistance evolution.

Keywords:
antibiotic resistancebacteriaevolutioninversionmutations

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Area of Science:

  • Microbiology
  • Pharmacology
  • Genetics

Background:

  • Antibiotic therapy presents a double-edged sword, effectively killing bacteria but also driving the evolution of antibiotic resistance.
  • The emergence of antibiotic resistance poses a significant threat to public health, limiting treatment options for bacterial infections.

Purpose of the Study:

  • To explore strategies for dissociating the therapeutic benefits of antibiotics from the risk of resistance evolution.
  • To investigate how specific drug interactions and resistance mutations can be exploited to combat antibiotic resistance.

Main Methods:

  • The study proposes leveraging known relationships between antibiotics and bacterial resistance mechanisms.
  • It highlights the potential of understanding how mutations conferring resistance to one antibiotic can alter sensitivity to others.

Main Results:

  • Exploiting cross-resistance and collateral sensitivity offers a novel approach to managing antibiotic resistance.
  • Genomic and diagnostic advancements are crucial for the practical implementation of these strategies.

Conclusions:

  • New therapeutic paradigms can be developed by understanding and manipulating drug-resistance interactions.
  • These approaches hold the potential to confine or even reverse the evolution of antibiotic resistance, preserving antibiotic efficacy.