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Is Atorvastatin Associated with New Onset Diabetes or Deterioration of Glycemic Control? Systematic Review Using Data

Angeliki M Angelidi1, Emelina Stambolliu1,2, Konstantina I Adamopoulou1

  • 1Society of Junior Doctors, Athens, Greece.

International Journal of Endocrinology
|November 15, 2018
PubMed
Abstract

Insights

Atorvastatin use is linked to an increased risk of new onset diabetes mellitus (NOD). High-dose atorvastatin may also worsen glycemic control in patients with existing diabetes mellitus (DM).

Area of Science:

  • Cardiovascular Pharmacology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Statins are associated with increased risk of new onset diabetes mellitus (NOD).
  • High-dose statin therapy can impair glycemic control in patients with diabetes mellitus (DM).

Purpose of the Study:

  • To review the effects of atorvastatin on NOD development.
  • To assess atorvastatin's impact on glycemic control in patients with DM.

Main Methods:

  • Systematic literature search of PubMed for primary studies published until April 2015.
  • Inclusion of 33 studies with 1,951,113 participants.

Main Results:

  • Twenty studies examined atorvastatin's effect on DM; half found no significant glycemic changes, while others showed increased fasting plasma glucose and HbA1c.
  • Thirteen studies investigated atorvastatin and NOD; most indicated a dose-dependent increased risk of NOD.

Conclusions:

  • Atorvastatin treatment is associated with an increased risk of new onset diabetes mellitus (NOD).
  • High-dose atorvastatin can lead to worsening glycemic control in patients with diabetes mellitus (DM).

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