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Randomized double-blind study of flunarizine versus placebo in patients with chronic cerebrovascular disorders
A Agnoli1, V Manna, N Martucci
1Department of Neurosciences, University of Rome La Sapienza, Italy.
International Journal of Clinical Pharmacology Research
|January 1, 1988
Abstract:
Chronic cerebrovascular disorders (CCVD), as defined by the 1980 Ad Hoc Committee in Paris, constitute both clinically and pathogenetically an extremely complex entity, characterized by a protean symptom pattern. The effects of a daily dose of 10 mg flunarizine orally on CCVD have been evaluated with a neuropsychological methodology during a three-month treatment period in a randomized double-blind study compared with a placebo. The results confirmed the effectiveness of the drug in the improvement of neurological, amnesic, attentive and behavioural symptoms, without evident side-effects even after a long-term treatment.