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Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
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Bilateral Vision Loss with p-ANCA Associated Lymphocytic Vasculitis
Andrew R Osborn1, Sejoon Jun1, Douglas C Miller2
1Mason Eye Institute, Department of Ophthalmology, University of Missouri School of Medicine, Columbia, MO, USA.
Ocular Immunology and Inflammation
|November 15, 2018
Summary
This case study highlights a patient with p-ANCA associated vasculitis presenting as bilateral vision loss. Early treatment with corticosteroids did not prevent unfavorable visual outcomes.
Area of Science:
- Ophthalmology
- Rheumatology
- Pathology
Background:
- P-ANCA associated vasculitis can present with diverse symptoms.
- Giant cell arteritis (GCA) is a common cause of vision loss in the elderly.
Observation:
- A 73-year-old woman experienced bilateral sequential vision loss.
- She presented with headache but no other systemic symptoms.
Findings:
- The patient tested positive for perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA).
- Bilateral temporal artery biopsy revealed lymphocytic infiltration.
- Despite prompt corticosteroid treatment, visual prognosis remained poor.
Implications:
- Consider ANCA associated vasculitis in cases of vision loss when temporal artery biopsy is inconclusive for GCA.
- Early diagnosis and treatment are crucial, though outcomes can be unfavorable.
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