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Cell Injection Millirobot Development and Evaluation in Microfluidic Chip.

Lin Feng1,2, Qiang Zhou3, Bin Song4

  • 1School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China. linfeng@buaa.edu.cn.

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|November 16, 2018
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Summary
This summary is machine-generated.

We developed a novel millirobot for precise cell nucleus suction, delivery, and injection within mammalian oocytes on microfluidic chips. This innovation enables controlled cellular manipulation with micronewton forces.

Keywords:
cell nucleuscell surgeryinjectionmagnetic controlmillirobot

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Robotics

Background:

  • Mammalian oocyte manipulation requires precise tools for procedures like nuclear transfer.
  • Existing methods for cell nucleus handling can be invasive or lack fine control.
  • Microfluidic platforms offer a controlled environment for cellular processes.

Purpose of the Study:

  • To design and demonstrate a novel millirobot capable of suction, delivery, and injection of donor cell nuclei.
  • To integrate millirobotic manipulation with microfluidic systems for oocyte procedures.
  • To achieve precise control over cellular components at the micron scale.

Main Methods:

  • A millirobot with a hollow body and nozzle was designed for cell nucleus absorption and ejection.
  • Magnetic and elastic forces controlled the hollow volume for suction and ejection.
  • The millirobot was integrated onto a microfluidic chip with XY plane stage control.
  • The system achieved three degrees of freedom and generated micronewton forces.

Main Results:

  • The millirobot successfully performed suction and ejection of 20-µm particles.
  • Magnetic control enabled precise manipulation of particles within the microfluidic chip.
  • The robot demonstrated controlled absorption and injection capabilities via its nozzle.

Conclusions:

  • The proposed millirobot design is effective for precise cell nucleus manipulation in mammalian oocytes.
  • This technology offers a promising tool for assisted reproductive technologies and cellular research.
  • The integration of millirobotics and microfluidics advances capabilities in cellular engineering.