Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibody Structure01:10

Antibody Structure

65.6K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.6K
Antibody Actions01:26

Antibody Actions

2.7K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
2.7K
Antibody Structure and Classes01:25

Antibody Structure and Classes

9.1K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
9.1K
Affinity and Avidity01:41

Affinity and Avidity

39.0K
Overview
39.0K
Humoral Immune Responses01:36

Humoral Immune Responses

83.9K
Overview
83.9K
Vaccinations01:51

Vaccinations

51.7K
Overview
51.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Multicenter Analysis of Patients with Bullous Pemphigoid: Clinical Characteristics and Insights into Drug-Associated Disease.

International journal of molecular sciences·2026
Same author

Deep learning based hair removal on ultraviolet-induced fluorescence dermatoscopy images.

Computer methods and programs in biomedicine·2026
Same author

Subcutaneous Thrombotic Vasculopathy with Features of Leukocytoclastic Vasculitis Following Intravenous Injection of Crushed Oxycodone and Methylphenidate Tablets: A Case Report with Literature Review.

Journal of clinical medicine·2026
Same author

A rare case of sporotrichosis in a patient with late latent syphilis and diabetes mellitus: immunological aspects of sporotrichosis.

Central-European journal of immunology·2026
Same author

Negative Maple Leaf-Like Areas are More Visible in Sub-UV Dermatoscopy - Further Applications and New Perspectives.

Dermatology practical & conceptual·2026
Same author

Generalized Cutaneous Lichen Amyloidosis in a Patient with an Ultra-Rare RET Y806C Variant Associated with MEN2A: A Case Report and Literature Review.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Feb 2, 2026

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
12:55

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries

Published on: January 17, 2015

19.2K

Morphea and antithyroid antibodies.

Aleksandra Dańczak-Pazdrowska1, Adriana Polańska2, Joanna Synakiewicz1

  • 1Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Postepy Dermatologii I Alergologii
|November 16, 2018
PubMed
Summary

This study found no significant link between morphea, an autoimmune skin condition, and increased antithyroid antibodies. Routine thyroid testing is not recommended for morphea patients.

Keywords:
anti-peroxidase antibodiesantithyroid antibodieslocalized sclerodermamorphea

More Related Videos

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test
07:54

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Published on: January 19, 2024

3.3K
Method for Whole Mount Antibody Staining in Chick
10:13

Method for Whole Mount Antibody Staining in Chick

Published on: February 2, 2009

16.3K

Related Experiment Videos

Last Updated: Feb 2, 2026

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
12:55

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries

Published on: January 17, 2015

19.2K
Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test
07:54

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Published on: January 19, 2024

3.3K
Method for Whole Mount Antibody Staining in Chick
10:13

Method for Whole Mount Antibody Staining in Chick

Published on: February 2, 2009

16.3K

Area of Science:

  • Dermatology
  • Immunology
  • Endocrinology

Background:

  • Morphea (localized scleroderma) is an autoimmune skin disease causing collagen overaccumulation and tissue thickening.
  • The relationship between morphea and other autoimmune conditions, particularly thyroid disorders, remains unclear.

Purpose of the Study:

  • To investigate the prevalence of elevated antithyroid antibodies in morphea patients.
  • To correlate antibody levels with clinical morphea manifestations.

Main Methods:

  • Analyzed 42 Caucasian morphea patients.
  • Measured thyrotropin (TSH), anti-peroxidase antibodies (TPO-Ab), anti-thyroglobulin antibodies (Tg-Ab), and TSH receptor autoantibodies (TRAb).

Main Results:

  • Elevated antithyroid antibodies were detected in a small percentage of patients: TPO-Ab (14.3%), Tg-Ab (9.5%), and TRAb (2.3%).
  • No significant difference in antithyroid antibody levels was observed between circumscribed and generalized morphea forms.

Conclusions:

  • Morphea, despite being autoimmune, does not appear to have a higher prevalence of positive antithyroid antibodies.
  • Routine laboratory screening for thyroid disorders in morphea patients is not indicated based on these findings.