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The morphology of cirrhosis: definition, nomenclature, and classification
Bulletin of the World Health Organization
|January 1, 1977
Insights
This article offers guidelines for defining, naming, and classifying cirrhosis, hepatic fibrosis, and chronic hepatitis. It emphasizes considering cirrhosis etiology and morphology together for a comprehensive understanding.
Area of Science:
- Hepatology
- Gastroenterology
- Pathology
Background:
- Cirrhosis, hepatic fibrosis, and chronic hepatitis are significant liver conditions.
- Standardized definitions are crucial for accurate diagnosis and research.
Purpose of the Study:
- To provide updated guidelines on the definition, nomenclature, and classification of cirrhosis, hepatic fibrosis, and chronic hepatitis.
- To clarify the complementary roles of etiology and morphology in cirrhosis classification.
Main Methods:
- Review and synthesis of existing literature and expert consensus.
- Development of a structured classification system.
Main Results:
- Proposed definitions for cirrhosis, hepatic fibrosis, and chronic hepatitis.
- Guidelines for classifying cirrhosis based on etiology (e.g., viral, alcoholic, autoimmune).
- Guidelines for classifying cirrhosis based on morphological characteristics (e.g., micronodular, macronodular).
Conclusions:
- A unified approach considering both etiology and morphology is recommended for cirrhosis classification.
- Standardized nomenclature and classification will improve clinical practice and research consistency.
Abstract:
This article provides guidelines on the definition, nomenclature, and classification of cirrhosis, hepatic fibrosis, and chronic hepatitis. Cirrhosis is considered according to its etiology and morphological characteristics, these being complementary rather than alternative.