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Related Experiment Video

Updated: Feb 2, 2026

Author Spotlight: Unveiling Neural Coding and Mechanisms of Visual Processing in the Superior Colliculus
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Auditory-visual convergence at the superior colliculus in rat using functional MRI.

Condon Lau, Francis A M Manno, Celia M Dong

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |November 17, 2018
    PubMed
    Summary

    The superior colliculus (SC) integrates auditory and visual information, as shown by functional magnetic resonance imaging (fMRI) in rats. This subcortical structure exhibits significant visual processing, laying groundwork for future noninvasive multisensory studies.

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    Area of Science:

    • Neuroscience
    • Sensory processing
    • Functional neuroimaging

    Background:

    • The superior colliculus (SC) is a midbrain structure known for multisensory processing.
    • Electrophysiology shows SC neurons respond to auditory, visual, and somatosensory stimuli.
    • Previous functional magnetic resonance imaging (fMRI) studies primarily focused on cortical multisensory processing.

    Purpose of the Study:

    • To investigate subcortical multisensory processing in the SC using blood oxygenation level-dependent (BOLD) fMRI.
    • To compare the SC's response to auditory and visual stimuli noninvasively.
    • To provide functional imaging evidence for auditory-visual convergence in the SC.

    Main Methods:

    • Applied BOLD fMRI on Sprague-Dawley rats.
    • Administered monaural auditory and binocular visual stimuli.
    • Analyzed activation patterns and BOLD signal changes in subcortical structures.

    Main Results:

    • Auditory stimulation activated the superior olivary complex, lateral lemniscus, inferior colliculus, and bilateral SC.
    • Visual stimulation activated the SC and lateral geniculate nucleus bilaterally.
    • SC activation (voxel count and BOLD signal change) was significantly greater for visual than auditory stimuli.

    Conclusions:

    • The SC is a site of auditory-visual convergence, involved in processing both sensory modalities.
    • fMRI activations in the SC likely represent both unisensory and multisensory neurons.
    • This study establishes a foundation for noninvasive functional imaging of multisensory convergence in the SC.